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Wren, Jonathan

One or more keywords matched the following items that are connected to Wren, Jonathan

Item Type	Name
Concept	Aging
Academic Article	Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline.
Academic Article	Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects.
Academic Article	Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.
Academic Article	Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.
Academic Article	The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Academic Article	Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.
Academic Article	CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging.
Academic Article	Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.
Academic Article	Sexually divergent DNA methylation patterns with hippocampal aging.
Academic Article	Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.
Academic Article	Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline.
Academic Article	Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice.
Academic Article	Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
Academic Article	The role of DNA methylation in epigenetics of aging.
Academic Article	Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice.
Academic Article	Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability.
Academic Article	Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection.
Academic Article	Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation.
Academic Article	IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.
Academic Article	Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.
Grant	Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging
Academic Article	Calorie restriction prevents age-related changes in the intestinal microbiota.
Academic Article	Oklahoma Nathan Shock Aging Center - assessing the basic biology of aging from genetics to protein and function.
Academic Article	Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging.
Academic Article	Characterization of the SARS-CoV-2 Host Response in Primary Human Airway Epithelial Cells from Aged Individuals.
Academic Article	Pharmacologic treatment with OKN-007 reduces alpha-motor neuron loss in spinal cord of aging mice.
Academic Article	Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.

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Healthy Aging